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Nature 396 (6710), 474477

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A more gradual approach may be recommended if you: Have experienced nausea with GLP-1 medications before Are sensitive to appetite suppressants Have a history of digestive issues Prefer a gentler adjustment period In these cases, remaining on the starting dose longer, or increasing in smaller steps, can significantly improve comfort

TRESIBA is available in 2 concentrations (U-100 and U-200): U-100 concentration is available in pen and vial The 100 units/mL pen can be injected from 1 to 80 units in a single injection, in increments of 1 unit