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Maintenance dose phase (10mg to 15mg) At maintenance doses, gastric emptying effects have largely plateaued

All care is physician-directed and focused on safe, sustainable weight management using evidence-based medical therapies

10.1002/ana.10784

It should be pinpointed that while GIP acts almost exclusively at the pancreatic level, there are widely distributed receptors for GLP-1 (R-GLP1) in the endocrine pancreas ( and ), in heart, stomach, adipose tissue, vagus nerve and in various regions of the central nervous system

N Engl J Med 389(6):514526 Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S et al (2023) Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA