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Effective dosing requires matching formulation strength to metabolic capacity

44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops

In severe cases, cognitive difficulties like confusion or dementia-like symptoms may develop

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