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These long-term benefits are harder to achieve with GLP-1 medicines alone, as many patients stop using the medications over time. According to the authors, the study has some limitations

This conjugate is not excreted as such in the urine but undergoes cleavage, first by the enzyme -glutamyl transpeptidase to release the free glutamyl residue and cysteinyl glycine derivative

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They also frequently used cheaper salt forms of the active ingredient that have not been clinically tested