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LDL circulating in the plasma appears to be protected from oxidation, both by dietary antioxidants such as vitamin E and C (259) and by protective enzymes including glutathione peroxidases (260,261), peroxiredoxins, PAF-acetylhydrolase (also known as lipoprotein-PLA2) (262,263), and paraoxonases (PON) (264,265)

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10.1007/s00117-024-01346-5 47 KonyaR.ReisR.SipahiH.BartaA.HohmannJ.KrmzbekmezH

Due to the scale being overwhelmingly tipped towards redox modulation, identification of a dose of APR-246 that allows for observation of a p53-specific effect is challenging

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