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Full-length HGH stimulates the liver to produce Insulin-Like Growth Factor 1 (IGF-1), which can induce cell proliferationa concern for long-term study regarding tumor growth

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FOXO4-DRI improves the testicular microenvironment in naturally aged mice FOXO4-DRI-treated aged testes showed decreased interstitial SA--gal activity (Figure 7A) as well as lower levels of senescence-associated proteins p53, p21, and p16 (Figure 7B7E)

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