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In the topline results released today, adults with diabetes who took orforglipron for 40 weeks had significantly better blood sugar control than those who took a placebo, according to a press release from Lilly

doi: 10.1186/s12917-024-04327-x 110 Rodrguez-VarelaCLabartaE

That extended residence time creates a perfect environment for bacterial fermentation

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However, the medication's gastrointestinal effects like diarrhea and constipation may indirectly contribute to conditions such as hemorrhoids or anal fissures that cause rectal bleeding