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67,68 The GSH-antibiotic conjugate is more water-soluble and can be expelled, reducing the effective drug concentration

doi: 10.1002/cpt1979264483

This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations

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