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In line with the previous findings, acute pharmacological inhibition of mTORC1 by rapamycin, which mimics a fasting-like state [65], activates POMC-GABAergic neurons while inhibiting POMC-glutamatergic neurons, implying that certain POMC neurons are activated in response to stimuli informing about a negative energy state, thereby promoting food intake [53]
Despite these findings, this use is not approved for medical treatment
Main exclusion criteria included recent gastrointestinal discomfort (e.g., abdominal pain or diarrhea) within the previous month, recent use of antibiotics, use of probiotics or prebiotics within the previous month, and advanced chronic kidney disease or other metabolic disorders (thyroid dysfunction, Cushing syndrome, acromegaly, and pheochromocytoma)
doi: 10.1097/HJH.0b013e3283569c5a