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doi: 10.1016/j.cell.2015.09.020 111 SinghRKaushikSWangYXiangYNovakIKomatsuMet al

Cell 21 , 17881798 (2010)

For long-term treatment, the maintenance dose may be further increased, with some individuals requiring up to 2 mg once weekly

HR, 0.78), with and without HF (HR, 0.75 vs

These systems discern the environmental stimuli signals, such as variations in pH, ionic strength, redox conditions, and the presence of specific proteins or enzymes, and consequently decide on the release of drugs