do some people not respond to semaglutide Why Ozempic Doesn't Help Lose Weight Why GLP-1 Therapy Isn't Working:

Clinical trials in adolescents have found GLP-1 medications can lead to significant weight loss when combined with lifestyle changes

The thigh's larger surface area makes systematic site rotation practical over weeks and months of weekly semaglutide therapy

Small, temporary lumps can also form where medication was depositedthese usually resolve on their own within a few days

Hypersensitivity Reactions Patients should be informed that serious allergic (hypersensitivity) reactions, such as angioedema, anaphylaxis, and exfoliative skin conditions, have been reported during post-marketing use of saxagliptin

The limitation is that GLP-1 drugs as approved by FDA are intended to treat obesity and diabetes, Lewis said