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--- In just five years, GLP-1s have gone from niche second-line agents to the dominant therapy class in type 2 diabetes

Using a method known as "target trial emulation," they compared patients initiating GLP-1 drugs with those initiating sodium-glucose cotransporter-2 (SGLT2) inhibitors or dipeptidyl peptidase-4 (DPP4) inhibitors

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-Butyrobetaine hydroxylase is the most studied enzyme among the four enzymes in the biosynthetic pathway

Effects of Semaglutide on chronic kidney disease in patients with type 2 diabetes