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For intermediate-stage disease, locoregional therapies are primarily recommended although systemic therapies may be preferred for patients with large intrahepatic tumor burden

Underlying Medical Conditions Thyroid disorders, hormonal imbalances, chronic inflammation, and sleep apnea can reduce the bodys responsiveness to weight loss interventions, even when using GLP-1 drugs

All other data are available from the corresponding authors upon request

Preclinical and early clinical investigations suggest that GLP-1RAs modulate neurobiological pathways underlying addictive behaviors, thereby potentially reducing substance craving and use while simultaneously addressing comorbid conditions

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