A significant negative latitude-dependent relationship was detected for carriage of the T allele, with occurrence of the cSHMT-C1420T polymorphic allele decreasing with increase in latitude ( r 2 =0.73, p 3R frequency in reported African and Eurasia studies found a significant negative relationship between latitude and frequency of the 3R allele ( r 2 =0.12, p =0.039) (Fig
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Further analysis in patients receiving only simvastatin (99 cases and 344 controls) did not reveal a significant association between either myopathy (OR = 1.12, p = 0.49) or severe myopathy (OR = 1.42, p = 0.24) with GATM ( GATM rs9806699 and the risk of rhabdomyolysis (OR = 1.01, p = 0.96) ( There are several factors that might lead to the differing results observed for GATM
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