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In the present study, using a HEK cell-based model for GNE myopathy, the role of Insulin-like Growth Factor Receptor (IGF-1R) as cell survival receptor protein was studied to counter the apoptotic effect of non-functional GNE

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doi:10.1210/jcem.84.4.5596 48

In response to stress, infection, trauma, or injury, microglia undergo phenotypic changes known as microglial activation and microglial polarization, which involve their conversion into pro-inflammatory (M1) and anti-inflammatory (M2) states (Zhou et al., 2020)