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Stroke 31(9):22122217

Furthermore, NET components (notably histones) directly activate platelets via Toll-like receptors (TLR2/4) and integrin signaling, increasing platelet aggregation and thrombin generationclosing a feed-forward loop in which platelets drive NET formation and NETs further activate platelets and coagulation [76]

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Given the impact of androgen excess on multiple reproductive and metabolic parameters of females, such analyses are deemed mandatory in order to define the potential utility of such compounds for the personalized treatment of women suffering from PCOS

This combination of effects explains why theyve become a valuable tool for treating Type 2 diabetes and why theyre now also being studied and prescribed for weight loss