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Following HGF-mediated dimerization and autophosphorylation of the c-Met receptor, signaling proteins are recruited to the carboxy-terminal docking site, either directly or indirectly through growth factor receptor-bound protein 2 (Grb2) and Grb2-associated binder-1 (Gab1)

Pretreatment of peripheral blood mononuclear cells from patients with MS with curcumin reduced IL-12 production and enhanced production of IL-10 induced by IFN- ( in vitro and in vivo studies showed the effectiveness of curcumin against the pathogenetic mechanisms of MS, and although further evidence from randomized controlled trials on curcumin efficacy is required, its role as an effective alternative treatment was suggested (Ghanaatian et al., 2019)

Bacteria was resuspended in DMEM without dilution, 0.2 mL of the bacterial suspension were added per dish

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93 Similarly, a truncation mutation (R3047X) located near Cys2991 in ATM results in insensitivity to oxidative stress