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Notably, adverse psychiatric symptoms, such as those observed in depression, activate the release of hypothalamic CRH (Gold 2021)

Disruptions in this delicate balance can precipitate thyroid dysfunctions, notably hypothyroidism

Cancer can affect any part of the body and may arise from various factors, including genetic mutations, environmental exposures, and lifestyle choices

A relevant issue that remains controversial is whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on the pancreas or other extrahepatic tissues, or direct, i.e., through activating GLP-1R on hepatocytes

So far, no oral GLP-1 weight-loss drug has been approved in China