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Deletion of IRS-1 gene in mice decreases both bone formation and resorption (18), whereas IRS-2 KO mice have reduced bone formation, but increased bone resorption (19), suggesting that different IRSs may be used by different types of bone cells

Yang L, Ye F, Liu J, Klionsky DJ, Tang D, Kang R (2022) Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis

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