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Steps to alleviate symptoms after vaccination To alleviate mild side effects, you can try the following: Apply a clean, cool, wet washcloth over the injection site to reduce swelling and pain Use or exercise your arm to help reduce discomfort Drink plenty of fluids Dress lightly to manage any fever Consider over-the-counter pain relievers like acetaminophen or ibuprofen, but only if you don't have any contraindications When to Speak to a Healthcare Provider The COVID-19 vaccine may cause mild side effects that can be treated with over-the-counter medications