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Organ meats such as liver and heart are the richest source of bioavailable B12 (16)

These changes result in increased left ventricular stiffness, which impairs diastolic relaxation and filling

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The specificity and effective in vivo concentrations of many natural products or small molecule agonists are debatable, with some effects possibly stemming from their broad-spectrum antioxidant capacity rather than genuine Nrf2-specific action