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1,6 Despite normal secretion of GLP-1 and GIP, the incretin effect is reduced or absent in people with type 2 diabetes, with the insulin-stimulating effect of GIP being more impaired when compared to GLP-1

They also temporarily speed up overall fat burn by up to 35 percent

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Then, the FDA's 2023 approval of Lilly's Zepbound (or tirzepatide, which is the active ingredient in diabetes treatment Mounjaro) made the weight loss market a two-horse race