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SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), significant on 4-point MACE (0.88) and all-cause death (0.84): Heerspink SURPASS-4 kidney post-hoc

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no single diet mandated per ADA 2026 Physical activity: 150 min/week moderate-intensity aerobic activity

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Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

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J Mol Med 95(3):323333 James R, Kesturu G, Balian G, Chhabra A (2008) Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options

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