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Instruct patients to notify their healthcare providers of new or worsening CV symptoms and to seek immediate medical attention if they experience signs and symptoms of MI or stroke [see Clinical Studies (14.10)]

This helps our team understand whether you require a lighter, sweeter, stronger or more neutral tobacco base

Finally, this review also revealed that more research is warranted to investigate the mechanistic effects of ETRPs in the context of thrombotic cardiovascular disease, and the pathways involved in such disease processes

Cardiovascular risks are a major concern, with studies linking smokeless tobacco to elevated heart rates and increased blood pressure