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Using sermorelin while on pegvisomant raises GH pulses that cannot produce IGF-1 feedback, risking prolonged GH excess

Can I combine my peptide therapy with another treatment for better results

Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]

A case report published in Physiological Reports (PMID 36303408) documented that co-administration of MK-677 and LGD-4033 in a 25-year-old male produced measurable increases in lean body mass (+3.1% trunk lean) alongside significant lipid and hepatic biomarker disruption, underscoring the importance of controlled research conditions when investigating sustained GHS-R1a stimulation

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