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Recent studies further connect sustained Ca 2+ entry (via NMDAR or P2X7) to loss of mitochondrial membrane potential, increased mitochondrial ROS, and suppression of mitophagic clearance, collectively potentiating NLRP3 activation in microglia under HIV-related conditions [100]

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These data collectively suggest that Ag-NPs can modulate the pruritus response by interfering with the nitric oxide pathway, proposing an alternative therapeutic approach to traditional antihistamines in the management of itch

10.3389/fcell.2021.667815 21 GaoN.ZhangZ.JiangB

Patients with endometriosis who follow the Mediterranean diet can reduce inflammatory factors in their bodies and alleviate pain symptoms (88)