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Preclinical studies in murine and human alveolar macrophages (AMs) have demonstrated that loperamide induced autophagy, enhancing its antimicrobial activity towards M.tb [12]

NAD+ is a critical coenzyme involved in hundreds of enzymatic reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation, as well as serving as a substrate for NAD+-consuming enzymes including sirtuins, PARPs, and CD38

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We therefore initiated treatment with BSO in the drinking water for both male and female -Myc mice at P21 and maintained it until 8 months of age, unless humane endpoints were reached

Return to non-strenuous work and driving typically takes four to six weeks