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A recent meta-analysis conducted by Winterlind, encompassing nine randomized controlled trials, found no notable advantage of NAC over placebo in alleviating cravings across various substance use disorders, despite its well-established modulation of glutamatergic and dopaminergic systems [81]

Consistent with the mRNA expression result, immunohistochemical analysis demonstrated a substantial reduction in ZO-1, Occludin, and Claudin-1 protein expression in the DSS group, which was effectively reversed by TLYY treatment (Figures 4D,E)

This endoscopic findings are inespecific but consistent of diverticular disease

However, an in vivo study on R

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