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DOI: 10.1111/dom.15728
The skin health tablets protect the skin from environmental stressors including UV rays and pollution
162,163,164 Exa-cel (Casgevy) was approved in November 2023 as the first gene-editing therapeutic drug based on the CRISPR/Cas9 system for treating sickle cell disease (SCD) and transfusion-dependent -thalassemia (TDT)
Following this, there have been two clinical phase 2 trials (SAR425899 and MEDI0382 also known as cotadutide) published evaluating GLP-1/glucagon receptor co-agonists
In dermal fibroblasts and ex-vivo skin, combining GHK-Cu with low-molecular-weight HA synergistically boosted collagen I/IV/VII, with collagen IV up 25.4 in cells and ~2 in ex-vivo skin, supporting topical maintenance after systemic cycles
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