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Cross-comparison of these datasets identified 3 specific histone acetyl marks H3K23ac, H4K8ac and H4K12ac that were specifically sensitive to regulation by this axis and validated by western blotting in multiple cell lines under different conditions ( Fig

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Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons

In addition, GLP-1R reduces gluconeogenesis by delaying gastric emptying and decreasing appetite, which also contributes to glycemic control (Xie et al., 2022)

Some protocols extend to 8-12 weeks with longer off periods