KA: Conceptualization, Writing review & editing
Factors such as advanced age, comorbidities, hemodynamic instability, and poor baseline functional status may limit tolerance
A notable example is the placebo-controlled trial by Bhasin et al., which demonstrated dose-dependent anabolic effects of supraphysiological testosterone enanthate administered for 10 weeks in healthy men, providing valuable mechanistic insight under rigorously controlled conditions but without addressing long-term safety outcomes ( Finally, most published studies focus predominantly on young men attending gyms, which limits the generalisability of findings to other populations, including women, adolescents, and individuals with differing health profiles or patterns of substance use
Titration phase and active side effects are reasons to wait a few weeks, not reasons to rule it out entirely
Amylin receptors are heterodimers of the class B calcitonin G protein-coupled receptor (CTR) and receptor-activity modifying proteins (RAMPs)