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An additional medium change was then accompanied by the addition of toxic concentrations of either NFT (Fig

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Secondly, mitochondria regulate redox balance, with balanced ROS production maintaining ECM integrity by modulating matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), while excessive mitochondrial reactive oxygen species (ROS) can lead to collagen fragmentation and elastin degradation [13,14,15]

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10.19621/j.cnki.11-3555/r.2018.0970 33 LiW.WangL.ChuX.CuiH.BianY

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