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Subsequently, the use of NAC was reported in a randomized clinical study, in which the effect of 4 weeks of oral supplementation of NAC (2400 mg/day) on the oxidative stress markers in adults with CF and chronic pulmonary infection was evaluated, where it was concluded that there was an improvement in pulmonary function, but without reductions in lipid peroxidation, malondialdehyde (MDA), and 8-isoprostane markers

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Twice daily dosage for optimal bioavailability and absorption

Informed consent was obtained from a parent of each child (who also assented to study participation)

doi: 10.1016/S0891-5849(99)00051-9