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In 2023, the European Union established a mandatory upper limit of 800 mg/day for EGCG in dietary supplements, following safety evaluations that revealed transaminase elevations in nearly a quarter of intervention trials at doses 800 mg/day

However, there is a crucial caveat: oral NAC is notorious for its sulfur-based composition and acidity, which can cause gastrointestinal discomfort, including nausea, vomiting, or acid reflux in a subset of users

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Clinical Evidence and Proposed Uses Research on oral glutathione tablets shows mixed results