Constella (linaclotide) CHMP assessment report
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[DOI] [PMC free article] [PubMed] [Google Scholar] 422.Lopez de Maturana R., Willshaw A., Kuntzsch A., Rudolph R., Donnelly D
Through iterative chemical synthesis and structural refinement, we developed a stabilized conjugate equipped with a C-terminal l-penicillamine residue and a self-immolative disulfide linker (GLP-1MK-801) (Extended Data Fig

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