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Donna Shelley, professor and vice dean for research at the New York University School of Global Public Health, said that while nicotine pouches don't cause the same health problems as products containing tobacco, she wouldn't call them "safe." "Some of the negative health effects of the nicotine pouches include gastrointestinal symptoms, like nausea, gum soreness and ulcers, and also some cardiovascular risks like elevated heart rate," said Shelley, who researches tobacco control, adding, "We don't know the full safety profile yet." A 2023 study that compared Zyn pouches to smokeless tobacco and nicotine replacement products found that while Zyn doesn't contain "nitrosamines or some of those real known cancer-causing agents, it does contain some chemicals like formaldehyde that the FDA has said are potentially harmful," she said

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Collectively, mitochondrial dysfunction and mitophagy impairment are inseparably linked, forming a pathogenic feedback loop that exacerbates neurodegeneration in NDDs

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