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Nicotine-free pouches eliminate the primary health risk of traditional pouches nicotine addiction and its associated cardiovascular effects

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Smoking is associated with a number of very serious health risks to both the smoker and to others around them

The observed causal link between cg04605617 methylation and QT interval prolongation suggests that alterations in DNA methylation at this locus may impact PLA2G2C expression and calcium ion kinetics in cardiac cells, which are integral to cardiac excitationcontraction coupling and have profound effects on cardiac electrophysiology [58, 59]

Adjustment variables Sociodemographic and smoking-related data were collected at each wave