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Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear

The drug was safe and well tolerated, and it even moved disease-related biomarkers in the right direction, but the clinical decline it was meant to slow continued largely unchanged

(2021, October 13)