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Furthermore, an estimated 8 million people are killed by tobacco particles annually, 7 million of whom die through direct tobacco use and 1 million of whom are non-smokers

Additionally, this review will also provide evidence that smoking has a mutagenic and an aneugenic effect on sperm and how this subsequently affects male fertility

Main outcome measures Birth weight and gestational age in singleton births

Histological examination of the testicular tissue revealed a significant reduction in the thickness of the seminiferous epithelium and seminiferous tubule diameter in response to nicotine exposure, which improved after nicotine cessation with negligible differences compared to the control group (Fig