The Centers for Disease Control and Prevention (CDC) states that there is no safe level of secondhand smoke exposure
Health problems related to using these products can include changes in the skin inside the mouth (smokeless tobacco keratosis), white patches in the mouth (leukoplakia), red patches in the mouth (erythroplakia), a slow-growing type of cancer that looks like a wart (verrucous carcinoma), and a common type of mouth cancer (squamous cell carcinoma)
Gingival Recession and Tooth AbrasionIn addition to the development of changes to the oral tissues, the use of smokeless tobacco can damage both the gum tissue and the teeth in the area where it is held in the mouth
In addition, tobacco smoking in asthma patients increased bacterial diversity in the lungs compared to healthy nonsmokers, suggesting smoking influenced lung microbiota composition
Furthermore, they seem to have the potential to be more predictive of effects in humans since they are derived from biopsied human cells and contain many of the relevant differentiated cell types not found in monolayer cultures
