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Chronic bronchitis treatments target your symptoms and include: Medications such as antibiotics, anti-inflammatories, and bronchodilators to open your airways A mucus-clearing device to help you cough up fluid more easily Oxygen therapy so you can breathe better Pulmonary rehab, an exercise program that can help you breathe more easily and exercise more Mucolytics, which are medicines you inhale or take orally to loosen mucus Bronchitis Prevention To lower your chances of getting acute bronchitis or a flare-up of chronic bronchitis: Stay away from cigarette smoke