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Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: final analysis of the phase 2b CENTAUR study

28 LOLA is a combination of endogenous amino acids that are metabolized in periportal and perivenous hepatocytes, where L-ornithine is utilized as a substrate in the urea cycle and acts as an activator of carbamoyl phosphate synthetase, the rate limiting enzyme of the urea cycle

This makes the drug a potential breakthrough for millions of patients who lack practical long-term solutions

It is hoped that this work will provide a reference for preclinical studies of MASH drugs and improve the translational success of new drugs

It is important to note that while GAC amino acids may have potential benefits, the scientific evidence supporting these claims is limited