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While emphasizing that e-cigarettes are not harmless for nonsmokers, the FDA and NIH recognize they could be a form of harm reduction and have called for more clinical trials into the safety and effectiveness of e-cigarettes as an aid in smoking cessation

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While vaping is safer than smoking, it still contains nicotine, which is relatively harmless in low dosages for smoking cessation but can cause uncomfortable (yet non-lethal) side effects in the body if consumed in large, unmonitored doses