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Subcutaneous injection of high doses of nicotine in mice achieving plasma concentrations similar to those of heavy smokers also increased epidermal thickness although lower nicotine doses simulating the plasma levels of lighter smokers had the opposite effect 29

A companion piece is listed in item 17CIN025-067

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Its worth noting that the estimates of cross-border trade in Europe (13 percent of menthol smokers) are self-reported (likely underreported due to illegality), and real illicit trade could be significantly higher in the U.S., since the size of the menthol market makes it a much more profitable market for illicit trade