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First, chronic inflammationprimarily mediated by neutrophils and macrophagesdirectly damages the epithelium and extracellular matrix (ECM) through proteases (e.g., MMPs, elastase), chemokines, and reactive oxygen species, thereby promoting structural destruction and airway narrowing

They argued that the customers who violated the rules should be the only ones penalised, and not them

The likelihood of contracting hepatitis C from sharing a joint or smoking after someone is relatively low, but it is still possible