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In addition, SIRT1 reduces oxidative stress and inflammation by inhibiting the nuclear factor kappa B (NF-B) signaling pathway, resulting in decreased production of inflammatory cytokines, including IL-1, interleukin-6 (IL-6), tumor necrosis factor (TNF-), and ROS (133135)

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It delivers the the same way as smoking a cigarette and can last for 300 puffs