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However, the study also noted that there was significant substitution with adolescents switching to either menthol cigarettes or other flavored combustible products like cigars, indicating that the public health impact would have been much stronger had the flavor ban applied to all combustible products as well as menthol cigarettes

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

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In terms of nicotine delivery from IQOS, a randomized crossover study showed that the nicotine delivery rate was similar between IQOS and CS with lower plasma nicotine peak after IQOS use (70% of CS peak) 87 , and another study reported a similar pharmacokinetic profile of nicotine from IQOS and CS with similar user satisfaction 88

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