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Therefore, the risk estimates may be biased downward because there are no truly unexposed persons

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Alternatively, VLP vaccines can also be made by producing blank VLP templates and then chemically linking antigenic peptides onto the pre-formed particles ( + T cells and CD4 + T helper cells leads to activation of cell mediated responses and B cells (and antibody production), respectively ( ( ( Figure 1 NP vaccines are produced by chemically crosslinking protein antigens and carrier molecules to increase immunogenicity and decrease degradation of the antigens ( Figure 2 ) ( Figure 2 DNA and RNA Vaccines Another promising area of vaccine development includes vaccines that are based on nucleic acids: DNA or RNA vaccines

2015 doi: 10.1007/s00429-014-0897-3