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FDA Commissioner Scott Gottlieb has already indicated that he wants to drive down smoking rates by making traditional cigarettes less addictive via cutting nicotine in them and offering US consumers safer alternatives to smoking

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Onion root tip cells exhibited reduced mitotic index, formation of micronuclei, lagging chromosomes, and c-mitosis.[] Chromosomal aberrations in PBL: Increased frequency of chromatid breaks, gap-type aberrations, and an increase in sister chromatid exchanges were observed in cultured PBL of male tobacco chewers,[] female masheri users,[] and mawa chewers with normal buccal mucosa, oral sumucous fibrosis, or oral cancer.[] A high proportion of tobacco processors with no tobacco habit and those with masheri habit exhibited a significantly elevated frequency of chromatid breaks and deletion fragments as compared to respective controls.[] SCE frequency was also elevated in the lymphocytes of habit-free tobacco processors.[] A significant increase in the frequency of chromosomal aberrations was observed in PBL from tobacco processors with or without smoking habits[] with the frequency of chromosomal aberrations increasing with the number of years of exposure