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But don't fall into the trap of making your strain choices based on the outdated folklore that "sativa is uplifting and indica is relaxing." Instead, consider the following: Cannabinoids : High-THC strains are the most intoxicating and are more likely to cause anxiety at high doses or in users with a low tolerance

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Due to its high toxicity, nicotine has been banned for use in the EU since 2010

This leads to decreasing bradykinin release and nociceptor stimulation

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